Medication-assisted treatment (MAT) is effective for managing opioid use disorder. The three medications approved for MAT include buprenorphine, methadone, and naltrexone. Methadone or buprenorphine paired with naloxone (Zubsolv, Bunavail, Suboxone) can be used during the maintenance phase of treatment. People on these drugs are still opioid-dependent, but they can often return to work, drive without impairment, and function normally in society.
Naltrexone (ReVia, Vivitrol) is an opiate receptor-blocking medication that can also be helpful during maintenance therapy. Unlike Methadone and Suboxone, naltrexone does not activate receptors so it does not make the person feel high, but it can help reduce cravings.